A teenager has died and her passenger seriously injured after a horrific crash involving a minibus and a car.

A Mercedes sedan collided with a Mitsubishi Rosa minibus at the intersection of Bussell Highway and Tuart Drive in Yalyalup, south of Perth, at 6.30pm on Saturday.

The driver of the Mercedes, an 18-year-old woman, sustained critical injuries and died at the scene.

Her 17-year-old female passenger was seriously injured and taken by ambulance to Bunbury Regional Hospital.

The mini-bus driver, a 23-year-old man, was uninjured.

Despite recent upgrades, the road is a notorious crash hotspot.

In April, a 40-year-old man died at the same intersection after his motorbike collided with another vehicle.

In March last year, a 69-year-old man died after his motorcycle was hit by a car. 

Residents called for the speed limit to be reduced from 110 km/h to 80km/h after a spate of accidents along the Bussell Highway, including the death of a 29-year-old man killed when a truck collided with his ute. 

Major Crash investigators are urging anyone with any information relating to the crash on Saturday to contact Crime Stoppers on 1800 333 000.