Epidemic Evolution: From Deadly Bacteria to Epidemic
Pseudomonas aeruginosa – an environmental bacterium known for causing severe multidrug-resistant infections, especially in individuals with pre-existing lung conditions – has rapidly evolved and spread globally over the past 200 years, likely driven by shifts in human behavior, a new study reveals.
P. aeruginosa accounts for more than 500,000 deaths annually worldwide, with over 300,000 linked to antimicrobial resistance (AMR). Individuals with chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and non-CF bronchiectasis are particularly vulnerable.
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‘Almost 70% of infections are caused by 21 genetic clones of P. aeruginosa, evolving rapidly and specializing in different lung environments. #Pseudomonas #lunghealth #medindia’
made our lungs more susceptible to infection and where there were more opportunities for infections to spread.
These epidemic clones have an intrinsic preference for infecting particular types of patients, with some favouring CF patients and other non-CF individuals. It turns out that the bacteria can exploit a previously unknown immune defect in people with CF, allowing them to survive within macrophages. Macrophages are cells that ‘eat’ invading organisms, breaking them down and preventing the infection from spreading. But a previously-unknown flaw in the immune systems of CF patients means that once the macrophage ‘swallows’ P. aeruginosa, it is unable to get rid of it.
Having infected the lungs, these bacteria then evolve in different ways to become even more specialised for a particular lung environment. The result is that certain clones can be transmitted within CF patients and other clones within non-CF patients, but almost never between CF and non-CF patient groups.
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Innovation Hub at the University of Cambridge and Royal Papworth Hospital NHS Foundation Trust, and senior author of the study said: “Our research on Pseudomonas has taught us new things about the biology of cystic fibrosis and revealed important ways we might be able to improve immunity against invading bacteria in this and potentially other conditions.
“From a clinical perspective, this study has revealed important information about Pseudomonas. The focus has always been on how easily this infection can spread between CF patients, but we’ve shown that it can spread with worrying ease between other patients, too. This has very important consequences for infection control in hospitals, where it’s not uncommon for an infected individual to be on an open ward with someone potentially very vulnerable.
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“We are incredibly lucky at Royal Papworth Hospital where we have single rooms and have developed and evaluated a new air-handling system to reduce the amount of airborne bacteria and protect all patients.”
Dr Aaron Weimann from the Victor Phillip Dahdaleh Heart & Lung Research Institute at the University of Cambridge, and first author on the study, said: “It’s remarkable to see the speed with which these bacteria evolve and can become epidemic and how they can specialise for a particular lung environment. We really need systematic, pro-active screening of all at risk patient groups to detect and hopefully prevent the emergence of more epidemic clones.”
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Source-Eurekalert