Influenza A Virus During Pregnancy Disrupts Maternal Intestinal Immunity and Fetal Cortical Development in a Dose- and Time-Dependent Manner
Researchers inoculated pregnant mice with two infectious doses of influenza A virus (IAV) and evaluated peak innate and adaptive immune responses in the dam and fetus. While respiratory IAV infection led to dose-dependent maternal colonic shortening and microbial dysregulation, there was no elevation in intestinal TH17 cells nor IL-17.