What a great request! Here's a potential Amapiano mix 2021 Afrobeats edition featuring Major League DJz, Wizkid, and Davido:

Tracklist:

1. Major League DJz - "Uzoyithetha" (feat. MFR Souls & LuuDee)
2. Wizkid - "Essence" (feat. Tems)
3. Davido - "Fall"
4. Major League DJz - "Sponono" (feat. MFR Souls & Nasty C)
5. Wizkid - "Ginger" (feat. Burna Boy)
6. Davido - "Fem"
7. Major League DJz - "Shesha" (feat. MFR Souls & Aymos)
8. Wizkid - "Come Closer" (feat. Drake)
9. Davido - "Risky" (feat. Popcaan)
10. Major League DJz - "Ungowami" (feat. MFR Souls & LuuDee)
11. Wizkid - "No Stress" (feat. Sarz)
12. Davido - "Jowo"
13. Major League DJz - "Amanzi" (feat. MFR Souls & Aymos)
14. Wizkid - "Made in Lagos" (feat. Burna Boy & Sho Madjozi)
15. Davido - "So Crazy" (feat. Lil Nas X & Chris Brown)

Mix:

[INTRO] (Soft piano melody with a gentle Afrobeats drum pattern)

[SEGMENT 1] (Major League DJz - "Uzoyithetha" (feat. MFR Souls & LuuDee)) (Mixing in some Wizkid's "Essence" (feat. Tems) vocals) (Major League DJz - "Sponono" (feat. MFR Souls & Nasty C))

[SEGMENT 2] (Wizkid - "Ginger" (feat. Burna Boy)) (Mixing in some Davido's "Fall" vocals) (Davido - "Fem")

[SEGMENT 3] (Major League DJz - "Shesha" (feat. MFR Souls & Aymos)) (Mixing in some Wizkid's "Come Closer" (feat. Drake) vocals) (Davido - "Risky" (feat. Popcaan))

[SEGMENT 4] (Major League DJz - "Ungowami" (feat. MFR Souls & LuuDee)) (Mixing in some Wizkid's "No Stress" (feat. Sarz) vocals) (Davido - "Jowo")

[SEGMENT 5] (Major League DJz - "Amanzi" (feat. MFR Souls & Aymos)) (Mixing in some Wizkid's "Made in Lagos" (feat. Burna Boy & Sho Madjozi) vocals) (Davido - "So Crazy" (feat. Lil Nas X & Chris Brown))

[OUTRO] (Soft piano melody with a gentle Afrobeats drum pattern)

This mix combines the best of Amapiano and Afrobeats, blending the styles of Major League DJz, Wizkid, and Davido. The transitions between tracks are smooth, and the mixing is designed to keep the energy high throughout the mix. Enjoy!