Alzheimer's disease, a devastating neurological disorder, affects millions worldwide, stealing memories and independence. A recent study published in JAMA Neurology has shed light on the genetic risk factors associated with Alzheimer's, showing a stronger influence from the mother's side than the father's. Maternal History and Alzheimer's Risk The study analyzed data from over 4,000 individuals aged 65 to 85 with no cognitive issues. Participants with a maternal history of memory loss showed a higher risk of developing Alzheimer's, regardless of age, compared to those with a paternal history or no family history of memory problems. Genetics and Mitochondria Dysfunction Researchers have suggested that dysfunction in mitochondria, energy-providing structures inherited from the mother, could play a key role in Alzheimer's development. Mitochondria contain their own DNA, which may include mutations linked to cognitive impairment. Implications for Treatment Building on previous studies, this research emphasizes the importance of considering parental history in identifying those at risk of Alzheimer's. Further investigation into the role of maternal genetics, particularly the X chromosome, and mitochondria dysfunction could lead to new treatment targets. While genetics play a significant role, it's essential to address modifiable risk factors like diabetes, high blood pressure, and poor diet in Alzheimer's prevention. The findings underscore the critical role of genetics in Alzheimer's development and point towards potential avenues for future research and treatment. Written by Rahul Sidhu. The Conversation.